Dr Thom Sharp leads the BioNanoPatterning group at the LUMC as assistant professor. He combines his acquired expertise in a range of methodologies to engineer complex protein assemblies, with the aim to understand the ultrastructure of the human innate immune system, and exploit this knowledge to develop strategies for activation, for instance to attack cancer cells or pathogens. Dr. Sharp uses Electron cryo tomography to directly visualize engineered protein structures and capture complement activation in the act. Besides this in vitro structural work, Dr Sharp also explores ways to combine super-resolution light microscopy with cryoEM to perform structural biology on individual proteins within cells. More information here