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NVMB Spring Meeting 2021

Mitochondrial physiology and pathology

The annual Spring Symposium of the NVBMB will be on Wednesday March 31st, as an online event 

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Mitochondrial physiology and pathology. In total, nine invited speakers will present their work. The lectures will discuss subjects ranging from the molecular to the clinical level. Examples include the biogenesis of the protein supercomplexes involved in oxidative phosphorylation, the assessment of mitochondrial bioenergetics at the single-cell level, the use of cellular and mouse models to investigate mitochondrial (dys)function in the context of aging and various pathologies, the clinical aspects of mitochondrial DNA mutations and the use of stem cell-based therapies to combat mitochondrial disease.

In addition, the winners of the H.G.K. Westenbrink prize 2018/2019 and 2019/2020 will give lectures about their research:

Liqin Wang (NKI): "A one-two punch model for cancer therapy"

João Medeiros Silva (UU): "Towards the physiologically relevant state with solid-state NMR"

Registration for the symposium is closed.

The NVBMB General Assembly will take place during the lunch break.

More information about the symposium is available through the organizers:
Merel Adjobo-Hermans (Radboudumc, on behalf of the NVBMB; merel.adjobo-hermans@radboudumc.nl)
Rob Wüst (VU Amsterdam, Department of Human Movement Sciences; r.wust@vu.nl)
Werner Koopman (Radboudumc, Department of Biochemistry; werner.koopman@radboudumc.nl).

Program

dowload a copy of the program here

09:30

Zoom-session open

09:50-10:00

Welcome (Merel Adjobo-Hermans, NVBMB/Radboudumc)

Session I: Mitochondrial supercomplexes (Chair: Rob Wüst)

10:00-10:30

- Ulrich Brandt (Radboudumc): OXPHOS complexomics

10:30-11:00

- Karin Busch (University of Münster): In cellulo OXPHOS protein interactions

11:00-11:30

- Daniele Bano (DZNE): Respiratory supercomplexes and single-cell assessment of mitochondrial bioenergetics

11:30-11:40

- Break

Session II: Mitochondrial disease (Chair: Merel Adjobo-Hermans)

11:40-12:10

- Clara van Karnebeek (Radboudumc): Clinical aspects of mtDNA-mutations

12:10-12:40

- Albert Quintana (Universitat Autònoma de Barcelona): Neuronal mouse models of mitochondrial dysfunction

12:40-13:40

- Yoga & Lunch (from 13:10-13:40)

- For NVBMB members only: NVBMB ALV-meeting from 13:10-13:40u

13:40-14:30

- H.G.K. Westenbrink prize ceremony & lectures “A one-two punch model for cancer therapy” by Liqin Wang (NKI); “tba” by João Medeiros Silva (UU)

Session III: New developments in mitochondrial research (Chair: Werner Koopman)

14:30-14:45

- Barry Bochner (BiOLOG)

14:45-14:55

- Break

14:55-15:25

- Amalia Dolga (RUG): Metabolic reprogramming in alpha-synuclein-dependent inflammatory processes

15:25-15:55

- Arie Nieuwenhuizen (WUR): Non-invasive and molecular assessment of skeletal muscle mitochondrial functioning in human ageing

15:55-16:25

- Bert Smeets (Maastricht UMC): Stem cell-based therapies in mitochondrial disease

16:25-16:30

- Closure

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