Dr. Lotteke Swier determined crystal structures of membrame-embedded ECF transporter with and without substrate, allowing her to decipher the molecular mechanism of transport. She used this knowledge to design and synthesize new substrates that modulate ECF transporter activity, which will very valuable in the development of new antibiotics. Dr. Swier is currently working as a postdoc in the oncology research group of Anke van den Berg at the University Medical Centre Groningen.