Lucy Shapiro is a Professor in the Department of Developmental Biology at Stanford University School of Medicine where she holds the Virginia and D. K. Ludwig Chair in Cancer Research and is the Director of Stanford’s Beckman Center for Molecular & Genetic Medicine. By studying the regulation of the cell cycle, asymmetric cell division, and cellular differentiation, Shapiro's pioneering work has led to a deep understanding of the genetic and molecular processes that cause identical bacterial cells to split into different cell types. These are basic processes that underlie all life, from single-cell bacteria to multi-cellular organisms. Her ideas have helped to develop novel drugs to fight antibiotic resistance and emerging infectious diseases. Lucy Shapiro has been actively involved in translating academic research on combatting infectious diseases to industry and has advised multiple US administrations.
Professor Shapiro will visit three Dutch universities:
Tue Sept 12th University of Groningen 15-16h
Lokaal 16, Onderwijs Centrum,University Medical Centrum Groningen, Groningen hosts: prof. Armagan Kocer (firstname.lastname@example.org) & prof. Dirk-Jan Slotboom (email@example.com)
Thu Sept 14th Vrije Universiteit / Netherlands Cancer Institute 16-17h
Main Auditorium O|2 bldg, De Boelelaan 1108, Amsterdam hosts: dr. Yves Bollen (firstname.lastname@example.org) & dr. Fred van Leeuwen (email@example.com)
Fri Sept 15th Leiden University 16-17h
Collegezaal 1, Gorleaus bldg, Einsteinweg 55, Leiden host: dr. Remus Dame (firstname.lastname@example.org)
3-D Systems Architecture of a Bacterial Cell Cycle
The cell cycle control logic in Caulobacter drives an integrated system that operates in time and space. Oscillating levels of temporally-controlled master regulators enable multiple cell cycle functions. Cell cycle regulation is, to a striking degree, a whole cell phenomenon with transcriptional circuitry interwoven with the 3-D deployment of phospho-signaling, which monitors the topology of the cell and is central to establishing asymmetric cell division. The overall regulatory ‘wiring diagram’ incorporates changes in DNA methylation state that enhance system robustness.