Cellular transcription programmes undergo profound changes both during differentiation of healthy cells and during the malignant transformation of diseased cells. This modulation of transcriptional outputs is orchestrated by changes in chromatin structure that operate at different yet interconnected levels: they affect the arrangement of the genome in the nuclear space, the activity and accessibility of enhancers and other regulatory elements and the function of transcription factors, chromatin-associated proteins, enzymes acting on chromatin and RNA. Recent advances have expanded our understanding of the underlying molecular processes but also have raised many new questions.
The 5th TRR81 symposium on “Chromatin Changes in Differentiation and Malignancies” in Bad Nauheim, Germany will provide a comprehensive view of the state-of-the-art and offer the opportunity for discussion with international leaders in the field.
More information can be found here:
http://www.uni-giessen.de/fbz/fb08/trr81/symposium_2019/symposium_program
